Not all PEGs are the same. Why monodispersity matters in peptide development

Monodisperse PEG purity profile

PEG linkers are widely used in peptide synthesis, bioconjugation and drug development. Their hydrophilic and flexible nature improve solubility, provide molecular spacing and help reduce aggregation and steric interactions. PEGylation can be used to modify the properties of peptide therapeutics, including their stability and circulation behaviour. (Ma et al., 2025) Not all PEGs are made … Read more

Monodisperse heterobifunctional PEGs of higher molecular weight for advanced pharmaceutical applications

Polypure monodisperse PEG derivative

Erik Agner, CEO Polypure AS The COVID-19 pandemic created a demand for a fast response to provide vaccines to a concerned world population. In this post, we will describe how Polypure developed monodisperse, heterobifunctional PEGs of higher molecular weights for advanced pharmaceutical applications based on the COVID-19 vaccine R&D project. The technology of mRNA incorporated … Read more