Fmoc-amino PEG-27 propionic acid ( CAS: 2101605-02-9)

Alternative names: Fmoc-NH-PEG28-acid; Fmoc-NH-PEG(27)-COOH; Fmoc-N-PEG27-
acid; Fmoc-amino PEG-27 acid; α-(9-Fluorenylmethyloxycarbonyl)amino-27(ethylene glycol)-ω-propionic acid

Molecular formula: C₇₄H₁₂₉NO₃₂

Application: Monodisperse Fmoc-amino PEG-27 propionic acid is a heterobifunctional PEG linker designed for peptide synthesis, bioconjugation, and drug development.

Fmoc-protected amine is fully compatible with standard Fmoc solid-phase peptide synthesis, enabling controlled, stepwise functionalization. The carboxylic acid group (-COOH) provides a versatile conjugation site for peptides, proteins, antibodies, oligonucleotides, and other biomolecules.

The monodisperse PEG spacer improves aqueous solubility, molecular flexibility, and reduces steric hindrance, facilitating the synthesis of long or aggregation-prone peptides and supporting the development of peptide therapeutics, antibody-drug conjugates (ADCs), peptide-drug conjugates (PDCs), cancer vaccines, targeted drug delivery systems, and other advanced bioconjugates.

The defined length ensures reproducible conjugation and simplified analytical characterization compared with conventional polydisperse PEG linkers.

Polypure’s Fmoc-amino PEG-27 propionic acid in publications:

Conibear, A. C., Hager, S., Mayr, J., Klose, M. H. M., Keppler, B. K., Kowol, C. R., Heffeter, P., & Becker, C. F. W. (2017). Multifunctional αvβ6 Integrin-Specific Peptide-Pt(IV) Conjugates for Cancer Cell Targeting. Bioconjugate Chemistry, 28(9), 2429–2439. https://doi.org/10.1021/acs.bioconjchem.7b00421

Bello, C., & Becker, C. F. W. (2017). A dual functional peptide-auxiliary conjugate for C-to-N and N-to-C sequential native chemical ligation of glycopeptides. Bioorganic & Medicinal Chemistry, 25(18), 5016–5021. https://doi.org/10.1016/j.bmc.2017.05.046

Redman, J. S., Francis, J. N., Marquardt, R., Papac, D., Mueller, A. L., Eckert, D. M., Welch, B. D., & Kay, M. S. (2018). Pharmacokinetic and Chemical Synthesis Optimization of a Potent d-Peptide HIV Entry Inhibitor Suitable for Extended-Release Delivery. Molecular Pharmaceutics, 15(3), 1169–1179. https://doi.org/10.1021/acs.molpharmaceut.7b01004